Acute 40% (PCDH19, GABRG2, anti-NMDAR encephalitis, mycoplasma post-infectious encephalitis), progressive 10% (RE), SE in defined electroclinical syndrome 30% (LGS, DR GE, non-ketotic hyperglycinemia), unknown 20% (NORSE/FIRES). The gene discussed is PCDH19; the disease is Lennox-Gastaut syndrome.