As STN patients may sustain greater cognitive decline after surgery, and current clinical practice and expert consensus provide the use of GPi-DBS in PD patients with a presurgical impaired cognition, a more cautious approach to PD-GBA1 patients by targeting the GPi could be considered and discussed between the clinicians, the patient, and his/her family, awaiting further literature evidence (19). This evidence concerns the gene GBA1 and Parkinson disease.