AKAP10 and Prolonged QT interval: Interestingly, genetic ablation of AKAP5 in mice with long QT syndrome 8, a condition characterized by sinus bradycardia, prolonged QT interval and lethal arrhythmias, was found to restore normal gating of Cav1.2 channels and to protect from arrhythmia [103], and AKAP10 (D-AKAP2) has been implicated in the control of cardiac rhythm both in mice and in humans [104].