Genetic gain of RyR2 or loss of calsequestrin function is associated with the pro-arrhythmic condition catecholaminergic polymorphic ventricular tachycardia (CPVT) experimentally recapitulated in murine hearts carrying genetically altered RyR2 or calsequestrin-2 [86,87]. The gene discussed is RYR2; the disease is catecholaminergic polymorphic ventricular tachycardia.