During PAH, there was a significant downregulation of Kv1.4, Kv4.2, Kv1.5 and ERG mRNAs in most tissues (figure 3g–j); Kv4.3 and KvLQT1 mRNAs were unchanged (data not shown). The gene discussed is KCND2; the disease is pulmonary arterial hypertension.