For example, FKBP12.6 did not influence susceptibility to stress-induced arrhythmia in rat myocytes [12], but FKBP12 and FKBP12.6 reduced spontaneous Ca2+ release in HEK cells, indicating a critical inhibitory regulation of RyR2 [16]. This evidence concerns the gene FKBP1B and Arrhythmia.