CAMK2G and atrial fibrillation: The objective of this study was to determine the role of the β activation-CaMKII-late INa pathway in the pathogenesis of AF underlying the β-adrenergic overactivity, and to explore the synergistic effect of combined inhibitions of late INa and CaMKII in alleviation of atrial electrophysiological malfunctions and severity of AF in denervated rabbit hearts and atrial myocytes.