In addition, RyR2 hyperphosphorylation by PKA or by CaMKII are the major causes of Ca2+-dependent arrhythmia such as catecholaminergic polymorphic ventricular tachycardia (CPVT) and VTs associated with HF [36,37]. The gene discussed is CAMK2G; the disease is catecholaminergic polymorphic ventricular tachycardia.