TXNL1 and ischemic stroke: In this study, we used in vivo laser speckle cortical imaging to evaluate the effect of TXL on no‐reflow after vascular recanalization in ischemic stroke induced by transient middle cerebral artery occlusion (tMCAO), and further explored the potential mechanisms of no‐reflow and TXL's protective effects against the phenomenon from the perspective of regulating leukocyte‐endothelial cell interactions.