Herein, we provide the first evidence that STING agonists (DMXAA and ADU-S100) drastically inhibits intrathecal opioid (morphine, fentanyl and sufentanil)-induced pruritus and these benefits do not come at the price of impairing optimal opioids antinociception and locomotor function. The gene discussed is STING1; the disease is Pruritus.