In this study, we characterized the potential role of intraperitoneal (i.p.)the murine STING agonist DMXAA and the cross-species STING agonist ADU-S100 in pruritus using acute itch models induced by opioids (morphine, fentanyl, sufentanil), and pruritogens (compound 48/80, chloroquine), and chronic itch models induced by dry skin and contact dermatitis. Here, STING1 is linked to Pruritus.