TNFRSF1A and multiple sclerosis: Here we report on the therapeutic potential of dual TNFR1-selective antagonism and TNFR2 agonism using the human TNFR1-selective antagonistic antibody H398 [16] and the mouse TNFR2-specific fusion protein EHD2-sc-mTNFR2 [17] in humanized TNFR1 mice induced with an animal model of multiple sclerosis.