To determine whether the strategy of antagonizing TNFR1 simultaneously with TNFR2 agonism was effective under neuroinflammatory conditions, an animal model of MS, EAE, was induced in mice in which the extracellular part of human TNFR1 is fused to the trans-membrane and intracellular region of mouse TNFR1, termed hu/m TNFR1ki [15]. Here, TNFRSF1A is linked to myeloid sarcoma.