SERPINA2 and hepatocellular carcinoma: To explore Acetyl-CoA metabolic reprogramming upon ER stress in HCC cells, we analyzed the expression patterns of acetyl-CoA metabolism-related genes (ARGs) in HCC tissues and adjacent non-cancerous tissues from three HCC cohorts, including TCGA-LIHC, ICGC-LIRI-JP and GSE101728 (Supplementary Fig. 1A).