CD4 and experimental autoimmune encephalomyelitis: Interestingly, antigen-nonspecific T cells, including myelin oligodendrocyte glycoprotein (MOG) tetramer–negative CD4+ Th17 cells, also infiltrate the central nervous system (CNS) in significant proportions and exacerbate experimental autoimmune encephalomyelitis (EAE) pathogenesis27–30.