MAPT and Alzheimer disease: Among the monotone regression splines with representative plasma biomarkers for AD (Aβ42, Aβ40, Aβ42/40 ratio, and total tau), the plasma Aβ42/40 ratio had a stable relationship with the progression of imaging biomarkers in women (except for slight fluctuation in cortical thickness at the initial stage), whereas there were no noticeable stable biomarkers in men (Supplementary Fig. 2).