Zeb1 knockdown abrogates the profibrogenic effect of MRTF-A in renal fibroblasts in vitro, whereas mice with myofibroblast-specific depletion of Zeb1 phenocopied the MRTF-AMFKO mice in two different animal models, pointing to Zeb1 as a downstream mediator of MRTF-A in FMyT and renal fibrosis. The gene discussed is ZEB1; the disease is renal fibrosis.