Although this finding is unlikely to be pathophysiologically significant in renal fibrosis because the epithelial lineage makes a negligible contribution to the myofibroblast pool in vivo, the similarity between EMT and FMyT corroborates our discoveries and confirmsthe pivotal role of MRTF-A in regulating/maintaining the myofibroblast phenotype. The gene discussed is MRTFA; the disease is renal fibrosis.