ZEB1 and renal fibrosis: However, Zeb1 depletion improved renal function, as determined by plasma BUN (Supplementary Fig. 11c) and creatinine (Supplementary Fig. 11d) levels, and mitigated renal fibrosis, as determined by qPCR measurements of profibrogenic gene expression (Supplementary Fig. 11e) and PSR/Masson’s staining (Supplementary Fig. 11f).