Myofibroblast-specific MRTF-A knockout mice (MRTFAMFKO) and control mice (MRTFAf/f) were subjected to unilateral ureteral obstruction (UUO) followed by tamoxifen injection for 5 consecutive days; the mice were sacrificed 2 weeks after the UUO procedure (Fig. 1A). This evidence concerns the gene MRTFA and Ureteral obstruction.