Experimental evidence in multiple cancers or cell lines suggests associations between activation of the genes and cell invasion and migration via different mechanisms: ANGPTL4 by regulating vascular permeability and angiogenesis61, TACC3 by promoting G1/S transition and the Wnt/beta-catenin pathway62, and THBS1 via interaction with tumor cell-bound CD4763. This evidence concerns the gene THBS1 and neoplasm.