The gene expression pattern was significantly different in adenomas and carcinomas, showing only 26 shared DEGs, including DMBT1, UCHL1, CEMIP, and DHRS2. Although we were not able to perform additional sequencing to check further somatic variants or CNAs due to a lack of available adenoma samples at this point, our findings support the notion that parathyroid carcinoma may commonly arise de novo rather than evolving from adenoma. The gene discussed is UCHL1; the disease is adenoma.