Moreover, they also showed that the use of empagliflozin as a sodium glucose cotransporter-2 (SGLT-2) inhibitor, which inhibits the SGLT-2 in proximal tubules to reduce Na+ and glucose re-uptake, in IR-induced AKI restored the renal tissue damage and KIM-1 expression [18]. Here, SLC5A2 is linked to acute kidney injury.