AHNAK2 and cancer: To further confirm functional proteins associated with drug efficacy and response, we identified 19 genes as cancer-related genes (CRGs) in PCa, whereas 15 were overlapped DEP/Gs (Fig. 3c), and four (TTN, NBPF14, AHNAK2, COL1A1) were the top mutated genes in PCMR (Fig. 2g, I).