SEMA4B and obesity due to melanocortin 4 receptor deficiency: To investigate if this novel pathway mediated by Sema4B cleavage by ADAM17 in adipocytes could have an impact in human obesity, we measured the mRNA levels of SEMA4B, PLEXIN (PLXN)B1 and 2, NEUROPILIN (NRP) 1 and 2, ADAM17, and of its known critical regulator iRHOM2 in human adipose tissues.