CXCL12 and neoplasm: Activation of SRC in tumor-associated macrophages is induced by tumor-derived cytokines and chemokines (e.g., TNF, MIP, SDF-1), which amplify the production of inflammatory cytokines (e.g., TNF, IL1β, IL6) to reciprocally activate SRC in a feed-forward loop and promote PDAC progression [28, 146].