Increased SRC expression is observed during the progression of chronic pancreatitis to PanIN and PDAC [135], while treatment of mice with the SRC kinase inhibitor PP2 significantly reduces the severity of caerulein-induced pancreatitis in mice and is associated with impaired activation of inflammatory signaling pathways (e.g., STAT3, ERK, NFκB) [136]. This evidence concerns the gene SRC and pancreatitis.