Mutations in cell cycle genes (for example TP53, RB1, CDKs or transcription factors from E2F family) can deregulate the cell cycle, which is an indication of four cancer hallmarks: Self-Sufficiency in Growth Signals, Insensitivity to Antigrowth Signals, Limitless Replicative Potential and Genome Instability9. This evidence concerns the gene TP53 and cancer.