CHD8 and cancer: We also observed that LoF alteration in the chromatin remodeling enzyme chromodomain helicase DNA-binding protein 8 (CHD8) sensitized cancer cell lines to inactivation of the exonuclease MRE11. Although this pair lacks confirmation from patient tests, it was supported by GDSC drug screen data where CHD8 mutated cell lines were more susceptible to the MRN complex inhibitor Mirin.