CEACAM5 and cancer: Taking the incidence of metastasis during the follow-up into account, no significant association was observed between colorectal cancer metastatic risk and the clinical characteristics and common cancer biomarker levels of the patients, such as age, sex, Duke, grade of differentiation, carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA 19-9) in the training cohort (Fig. 4e).