Recent studies emphasize that several types of tumor infiltrating lymphocytes (TIL) are associated with better disease outcomes for various human cancers68,69, It indicates that more CD3+, CD8+ or CD45RO + T cells in tumor tissue are significantly associated with lower frequency of lymph node metastasis, disease recurrence or longer survival of patients. This evidence concerns the gene CD8A and metastatic malignant neoplasm in the lymph nodes.