TET1 and hepatocellular carcinoma: Unexpectedly, TET1-CD alone, either tethered to SpdCas9, or recruited by the MS2-MCP system, or even concomitantly fused and recruited, was unable to de-repress any of the TSGs targeted in either of the two HCC lines transiently transfected along with the most potent gRNA/s or with no gRNA as control (Fig. 5B–H).