To correlate the extent of TSG re-expression with cancer cell phenotypic remodeling, Hep3B cells transduced with SpdCas9-VPR targeting HHIP or the multiplexed four TSGs (HHIP, MT1M, PZP, and TTC36) were processed by cell proliferation, cell viability, and cell migration assays. This evidence concerns the gene HHIP and cancer.