As observed in HCC clinical specimens, these lines demonstrated downregulation of several TSG’s mRNAs relative to non-transformed hepatocytes, particularly HHIP, miR-122-5p, MT1E, MT1M, PZP, and TTC36 in Hep3B, and HHIP, PZP, TMEM106A, and TTC36 in HuH-7 cells (Fig. 2A). Here, TMEM106A is linked to hepatocellular carcinoma.