In this study, we bioinformatically analyzed a panel of 12 candidate TSGs (BCO2, CDKN2A, CPS1, HHIP, miR-122-5p, MT1E, MT1M, PSAT1, PTGR1, PZP, TMEM106A, and TTC36) that are epigenetically silenced and under-expressed in HCC tumor samples compared to normal tissue. The gene discussed is CDKN2A; the disease is hepatocellular carcinoma.