SERPINB5 and gastric cancer: This versatile system has been exploited for specific re-expression of several loci by expression of multiple gRNAs targeting different TSGs, such as MASPIN in lung cancer cells [18], RPRM in gastric cancer cells [18], PTEN in triple-negative breast cancer and melanoma [19], DKK3 in prostate cancer [20], and CCN6 in a mouse model of breast cancer [21].