Importantly, the TRPV1 blockade-synergized thermotherapy from IS-Micelles led to the potent suppression of recurrent tumors as compared to the thermotherapy alone from I-Micelles, as evidenced by the decreased bioluminescence signals and tumor weights at the end of the experiment (Fig. 4i, j), further validating distinct synergy between TRPV1 blockade and thermotherapy. This evidence concerns the gene TRPV1 and neoplasm.