Clearly, negligible green fluorescence from HSF1 in the nucleus was observed in the cells treated with IS-Micelles under light irradiation, whereas I-Micelles as a control displayed distinct nuclear distribution of HSF1 in the presence of light exposure, as validated by high co-localization of green and blue fluorescence (Fig. 7a, b), suggesting the effectiveness of TRPV1 blockade to suppress HSF1 nuclear translocation upon hyperthermia in PANC02 tumor cells which highly express TRPV1 ion channels (Supplementary Fig. 36). The gene discussed is HSF1; the disease is neoplasm.