TRPV1 and pancreatic neoplasm: Inspired by the effective relief of immunosuppression and robust activation of antitumor immune response in subcutaneous PANC02 pancreatic tumor models, we further explored the potency of TRPV1 blockade-synergized thermo-immunotherapy against highly aggressive orthotopic PANC02-Luc pancreatic tumor model (Fig. 9a).