TRPV1 and neoplasm: To investigate the synergistic effect of SB705498-mediated TRPV1 blockade on the thermotherapeutic potency in vivo, A549-WT cells or A549-TRPV1 KD cells were injected subcutaneously into the nude mice to establish A549-WT tumor or A549-TRPV1 KD tumor models, respectively.