Moreover, IS-Micelles exhibited a relatively low release of SB705498 at pH 7.4, while the increased releases of SB705498 from IS-Micelles were observed at pH 6.5 and 5.5 due to the enhanced solubility of SB705498 at acidic pH (Fig. 3d), thereby contributing to tumor microenvironment-activatable release for effective TRPV1 blockade. Here, TRPV1 is linked to neoplasm.