To generate potent hyperthermia for yielding cancer thermotherapy, the albumin nanoparticles caging copper sulfide nanocrystals (CuS-NCs) were constructed as a photothermal source as described previously25,26, which possessed the core size of 7.8 nm and hydrodynamic diameter of 25.4 nm (Supplementary Fig. 1a). The gene discussed is ALB; the disease is cancer.