In contrast, through the efficient co-delivery of TRPV1 antagonist, the tumor cells in the group of IS-Micelles displayed no distinct change of HSP70 expression as compared to that of PBS upon irradiation (Fig. 3i, j), suggesting that IS-Micelles are able to block stressful HSP70 overexpression through valid TRPV1 blockade for surmounting thermo-resistance. The gene discussed is TRPV1; the disease is neoplasm.