Upon irradiation, IS-Micelles resulted in the reduced migration of tumor cells as compared to I-Micelles, revealing that both TRPV1 blockade and hyperthermia from IS-Micelles synergistically contribute to distinctly decreased occurrence of cell metastasis (Supplementary Fig. 33), possibly due to the involvement of TRPV1 blockade-synergized thermotherapy in metastasis-relevant EMT pathways (Fig. 2e). This evidence concerns the gene TRPV1 and neoplasm.