CD80 and neoplasm: Meanwhile, PANC02 tumor was found to harbor a large proportion of CD11b+F4/80+CD206+ TAMs (M2-like character), while the IS-Micelles/aPD-L1 combination led to more efficient repolarization of macrophages from M2-like TAMs to CD11b+F4/80+CD80+ TAMs (M1-like character) in PANC02 tumor upon light irradiation, as compared to IS-Micelles alone or I-Micelles/aPD-L1 combination regardless of light irradiation (Supplementary Fig. 42b–d), manifesting the shift of macrophages from protumor to antitumor phenotype62.