Furthermore, tumor-selective TRPV1 blockade using polymeric micelles incorporating both indocyanine green (ICG) and TRPV1 antagonist yields considerable antitumor potency against a variety of primary tumors (e.g. breast, liver, colorectal, and pancreatic tumors), metastatic tumors, and recurrent tumors under light exposure, together with superior safety. The gene discussed is TRPV1; the disease is metastatic neoplasm.