The IS-Micelles/aPD-L1 combination caused a distinctly improved frequency of CTLs (CD45+CD3+CD8+ T cells) in the tumor upon light exposure (Supplementary Fig. 42f), displaying 1.15-fold and 1.2-fold increases as compared to IS-Micelles alone or I-Micelles/aPD-L1 combination under light irradiation, respectively. Here, CD8A is linked to neoplasm.