APOE and Wilson disease: To distinguish effects associated with IP angiogenesis and hemorrhages from other mechanisms, ApoE−/−Fbn1C1039G+/− mice were randomly divided over two treatment regimens, a shorter protocol covering 12 weeks of WD (IP angiogenesis is not occurring yet, or recently initiated) and a longer protocol up to 20 weeks of WD (IP angiogenesis frequently occurring in carotid plaques from ApoE−/−Fbn1C1039G+/− mice).