For instance, in a murine renal cell carcinoma model and in castration-resistant prostate cancer, Pili et al. [18] showed that entinostat, in combination with either IL-2, survivin-based vaccine therapy, or immune checkpoint inhibition, reduced Foxp3 levels in Tregs, and this was associated with enhanced tumor growth inhibition. This evidence concerns the gene IL2 and Familial prostate cancer.