Inclusion of 5-AZA and entinostat in the treatment regimen did result in a significant decrease in tumor-infiltrating FoxP3+ Regulatory T cells (Tregs) and circulating granulocytic myeloid-derived suppressor cells (G-MDSCs), compared to either untreated tumors or tumors treated with immune checkpoint blockade alone. The gene discussed is FOXP3; the disease is neoplasm.