Before PSM, after adjusting for other confounding variables such as age, gender, HR, creatinine, WBC, Hemoglobin, NT-proBNP, hypertension, hyperlipidemia, cardiogenic shock, SOFA score and CRRT, age, HR, creatinine level, cardiogenic shock, overweight, and obesity were independent predictors of 90-day mortality in patients with SA ≥ 3.5 g/dL (Fig. 2a). This evidence concerns the gene NPPB and obesity due to melanocortin 4 receptor deficiency.