Thus, we first confirmed the expression of IL-9R in TH9 clones primed in vivo (Fig. 5a), circulating CXCR3−/CCR4+/CCR8+ effector memory TH cells (Fig. 5b), and TH cells infiltrating lesions of ACD (Fig. 5c, d), showing that pTH2 and TH9 cells are important targets of IL-9 in human skin inflammation. This evidence concerns the gene CXCR3 and granular corneal dystrophy type II.