Anaplastic lymphoma kinase (ALK) is a well-known driver oncogene in anaplastic large cell lymphoma (ALCL), non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) and has been identified in other types of tumors, including inflammatory myofibroblast tumor (IMT), epithelioid inflammatory myofibroblast sarcoma (EIMS), and epithelioid fibrous histiocytoma (EFH). The gene discussed is ALK; the disease is inflammatory myofibroblastic tumor.