Anaplastic lymphoma kinase (ALK) is a well-known driver oncogene in anaplastic large cell lymphoma (ALCL), non-small cell lung cancer (NSCLC) and renal cell carcinoma (RCC) and has been identified in other types of tumors, including inflammatory myofibroblast tumor (IMT), epithelioid inflammatory myofibroblast sarcoma (EIMS), and epithelioid fibrous histiocytoma (EFH). This evidence concerns the gene ALK and renal cell carcinoma.