Although long-acting insulin analogues like glargine and detemir do not peak and are unlikely to lead to hypoglycemia in the perioperative fasting state, to be safe and minimize the risk of hypoglycemia, the recommendation is to reduce the dose by 20–30% the night before and the day of surgery, if on a twice daily dosing (Barker et al. 2015; Vann 2014; Demma et al. 2017). Here, INS is linked to Hypoglycemia.