TP53 and intrahepatic cholangiocarcinoma: For the intermediate ICC group, we compared CpGs in enhancers relative to promoters (determined by H3K4me3 presence), which revealed that enhancer CpGs are enriched for protein kinase A and PPAR signaling pathways while promoters are enriched for p53 signaling and antigen presentation pathways (Additional file 2: Fig. S9D).