These results reveal greater divergence within tumor samples than normal kidney, and within tumors SETD2 wt ccRCC manifests with significantly larger Euclidian distances than SETD2 mt ccRCC (μEDwt = 86.88, μEDmt = 77.51, p = 1.98 × 10–5). Here, SETD2 is linked to nonpapillary renal cell carcinoma.