Ontology analysis reveals that ccRCC DMCpGs map to genes linked to tumor driver and anticancer therapy pathways including PD-1 immunotherapy, invasion/metastasis (epithelial-mesenchymal transition (EMT) and CXCR4 signaling), and inflammation (interferon and IL8 signaling, Fig. 2G). Here, CXCR4 is linked to nonpapillary renal cell carcinoma.