Indeed, genes linked to normal kidney epigenetic heterogeneity are weakly enriched in specific pathways, including tumor-relevant pathways, whereas genes linked to enhancers subject to epigenome ITH are highly enriched in cancer-related pathways like epithelial-to-mesenchymal transition and CXCR4 signaling that may influence metastatic potential [49]. The gene discussed is CXCR4; the disease is cancer.