For example, USP44, a ubiquitin-specific protease that is hypermethylated in the most terminal/progressed branches of patient m11 (Fig. 5B, left), is known to be downregulated and hypermethylated in ccRCC, and USP44 expression is negatively correlated with ccRCC stage, grade, and patient survival [39]. The gene discussed is USP44; the disease is nonpapillary renal cell carcinoma.