SETD2 and nonpapillary renal cell carcinoma: This difference in variability is also observed when tumors are stratified according to SETD2 genetic status (Fig. 4B), with the median SD of CpGs in the SETD2 wt ccRCC group being significantly higher than that in the SETD2 mt group of tumors (p < 2.2 × 10–16).