SETD2 and neoplasm: For the remaining pathologic categories (varying on a per region basis), H3K36me3 levels were significantly underrepresented in SETD2 mt tumors (p < 0.01), while SSIGN score (p = 0.174), tumor grade (p = 0.762), and necrosis (p = 0.325) did not differ between sequence confirmed SETD2 wt and mt tumors.