Oncostatin M (OSM) is a member of the interleukin (IL)-6 family and interacts with the functional receptor complexes of shared the signal transducing component glycoprotein 130 (gp130) and OSM receptor β (OSMR) or leukaemia inhibitory factor receptor (LIFR), which functions as a key regulator of communication in target cells in inflammatory and various cardiovascular diseases, including aortic stenosis, myocardial infarction, myocarditis, cardiac sarcoidosis, and various cardiomyopathies [8]. The gene discussed is OSMR; the disease is cardiovascular disorder.