In the present study, we observed that the coexpression of LIFR and F4/80 was augmented in an in vivo mouse AB model and cultured BMDMs with OSMR knockout, which was accompanied by the upregulation of OSM and the phosphorylation of STAT3, indicating the involvement of macrophage-associated STAT3 in OSMR deletion-regulated cardiac hypertrophy. This evidence concerns the gene LIFR and cardiac hypertrophy.