NOTCH1 and cardiovascular disorder: Genome editing technologies, such as zinc finger nucleases, transcription activator-like effector nucleases (TALEN), and clustered regularly interspaced short palindromic repeats (CRISPR) methodologies, have been applied to both WT and patient-derived iPSCs to study the effect of risk variants in a range of cardiovascular disease models, including BLC2-associated athanogene 3 (BAG3) gene in dilated cardiomyopathies and Notch Receptor 1 (NOTCH1) gene in congenital valvular disorder [61, 64, 99].