PITX2 and Stroke: Other stroke subtypes specific variants include SNPs in both the paired-like Homeodomain Transcription Factor 2 (PITX2) and the Zinc Finger Homeobox Protein 3 (ZFHX3), both of which were initially associated with atrial fibrillation, a well-recognised risk factor for stroke, and then found to be associated with the cardioembolic stroke subtype [19].