Recently, Bai's team showed that the CRC cell HCT-116-derived CEXs miR-128-3p could promote EMT by downregulating the FOXO4 expression and activating the transforming growth factor-β (TGF-β)/SMAD and JAK/STAT3 signaling pathways [20]. Here, TGFB1 is linked to colorectal carcinoma.