A study reported that the M2 macrophage-derived exosome miR-155-5p could promote the proliferation and anti-apoptotic activities of SW48 and HT29 cells; it was also confirmed in xenograft tumor models that exosomal miR-155-5p decreased the expression levels of ZC3H12B and upregulated IL-6 levels, thereby accelerating the induction of immune escape and CRC occurrence [36]. The gene discussed is IL6; the disease is colorectal carcinoma.