Recently, a study reported that the CAF-derived exosomal cricN4BP2L2 promoted the resistance of CRC LoVo cells to oxaliplatin by upregulating EIF4A3, leading to the activation of PI3K/AKT/mTOR signaling pathway, while inhibiting the development of apoptosis [49]. This evidence concerns the gene AKT1 and colorectal carcinoma.