According to univariable analysis, five risk factors including diabetes (OR, 3.32; 95% CI, 1.21–9.09; p = 0.02), lower serum level of albumin (OR, 3.37; 95% CI, 1.11–10.23; p = 0.032), distal pancreatectomy (OR 6.32, 95% CI 2.22–18.04; p = 0.001), residual tumor (OR 7.12, 95% CI 3.24–15.66; p < 0.001) and anastomotic level from anal verge shorter than 10 cm (OR, 5.48; 95% CI, 1.89–15.87; p = 0.002) were associated with AL (Table 3). The gene discussed is ALB; the disease is diabetes mellitus.