ADCY1 and Neurodevelopmental delay: Significant functional annotation enrichment was observed in KEGG term Neuroactive ligand-receptor interaction p = 1.03E − 8, Reactome term GPCR ligand binding p = 5.39E − 7; GO Process term modulation of chemical synaptic transmission p = 3.14E − 5; GO Function term G protein-coupled receptor activity p = 4.97E − 5; GO process term behavior p = 1.5E-4, and; GO Process term Adenylate cyclase-modulating g protein-coupled receptor signaling pathway p = 1.8E − 4, suggesting high level of complexity among the gene signaling networks involved in NDD.