SH3TC2 and Charcot-Marie-Tooth disease type 4C: The SH3TC2 (SH3 domain and tetratricopeptide repeats-containing protein 2) protein is thought to be expressed in Schwann cells, protective glia that support neuronal function, and is best known for its association with the childhood neurodegenerative disease Charcot-Marie-Tooth disease type 4C as well as sensory and motor neuropathy [25, 26].