ADRB2/SH3TC2, CACYBP, and FSCN1 deletions were exclusively enriched within the ADHD cohort while PCBP3 duplications were enriched within the NDD cohort; ADRB2, SH3TC2 deletions were observed in 50 cases and 5 controls (1.94E − 9; OR = 8.89, CACYBP deletions in 24 cases and 0 controls (2.71E − 7, OR = infinity), FSCN1 deletions in 32 cases and 2 controls (P = 2.70E − 7; OR = 14.16). This evidence concerns the gene ADRB2 and attention deficit-hyperactivity disorder.