It should be mentioned that although treatment with hydrogels relieved AD symptoms, in the HCPF group, skin lesions (Fig. 6), inflammatory markers (such as TSLP and IL-4, Fig. 7b, d), and intercellular junctions (Fig. 7g, i) are still not restored to the level of healthy mice. The gene discussed is TSLP; the disease is Alzheimer disease.