In the Study of Latinos—investigation of Neurocognitive Aging (SOL-INCA), we previously saw that MCI was not associated with the strongest AD genetic risk factor, the APOE-∈4 allele [7, 8], while an AD polygenic risk score constructed using single nucleotide polymorphisms (SNPs) mainly from the APOE region, was associated with MCI [9]. The gene discussed is APOE; the disease is Alzheimer disease.