The induced intrinsic force from the cytoskeleton can directly influence transcription in the nucleus via nuclear lamina (e.g., lamin A) or activate transcription regulators (e.g., megakaryocytic acute leukaemia (MAL)) and translocate them into the nucleus.[36, 77] SRF‐MAL, which is associated with serum response factor (SRF) in the nucleus, drives changes in gene expression and mediates cell behaviors. The gene discussed is MAL; the disease is acute megakaryoblastic leukemia.