Studies have also revealed contradictory findings during different infections: hereditary deficiency in Toll-like receptor 3 (TLR3)—and TANK-binding kinase 1 (TBK1)-mediated type I IFN signaling [161] are associated with resistant type I IFN signaling in severe COVID-19 infection patients [59]. The gene discussed is TLR3; the disease is hyperinsulinemic hypoglycemia, familial, 4.