Screening for complications could include liver (fibrosis-4, NAFLD fibrosis risk score), cardiovascular (blood pressure, lipid profile, BNP), metabolic (HbA1c, fasting glucose), reproductive (sex-hormone binding globulin, testosterone etc.), sleep (Epworth sleepiness scale), arthritis (AIMS/AIMS2—Arthritis Impact Measurement Scales), mental health (PHQ-9) and socioeconomic complications (Simple questionnaire evaluating economic impact). The gene discussed is SHBG; the disease is Arthritis.