After PSM, among ischemic stroke patients > 65 years old, CRP levels 1–3 mg/L and > 3 mg/L, were associated with higher risk of early cardiac complications or death (HR 1.11, 95% CI 1.05–1.17 and HR 1.44, 95% CI 1.37–1.51, respectively). This evidence concerns the gene CRP and ischemic stroke.