In the exploratory analysis after excluding patients who had experienced the cardiovascular outcome of interest before the index ischemic stroke, the primary composite outcome of new cardiac complications or death occurred in 11.4% of patients with CRP levels > 3 mg/L compared to 6.4% among those with CRP levels < 1 mg/L (HR 1.81, 95% CI 1.63–2.01). The gene discussed is CRP; the disease is ischemic stroke.