After PSM, among ischemic stroke patients without connective tissue disorders, recent infections or associated treatments (glucocorticosteroids/antibiotics), CRP levels 1–3 mg/L and > 3 mg/L, were associated with higher risk of early cardiac complications or death (HR 1.13, 95% CI 1.04–1.23 and HR 1.40, 95% CI 1.30–1.52, respectively). The gene discussed is CRP; the disease is infection.