Ischemic heart disease were more common among patients with CRP levels > 3 mg/L compared to those with CRP < 1 mg/L (HR:1.33, 95% CI:1.26–1.40), while no association with Takotsubo cardiomyopathy was found in all the analyses. The gene discussed is CRP; the disease is Tako-tsubo cardiomyopathy.