For secondary outcomes, in patients with CRP levels > 3 mg/L the significative higher risk for ischemic heart disease (HR 1.52, 95% CI 1.32–1.75), HF (HR 1.84, 95% CI 1.57–2.15), AF (HR 1.36, 95% CI 1.17–1.59) and ventricular arrhythmias (HR 1.69, 95% CI 1.24–2.31) compared to those with CRP levels < 1 mg/L remained consistent, as well as the lack of any association with Takotsubo cardiomyopathy (HR:1.83, 95% CI:0.68–4.96) (Fig. 1). This evidence concerns the gene CRP and Tako-tsubo cardiomyopathy.