After PSM, among 33,138 patients, the primary composite outcome of cardiac complications or death within 30 days of the index ischemic stroke were reported in 4243 (25.6%) patients with CRP levels 1–3 mg/L compared to 3891 (23.5%) among those with CRP levels < 1 mg/L (HR 1.10, 95% CI 1.05–1.15). This evidence concerns the gene CRP and ischemic stroke.