Analyzing the risk for secondary outcomes (each component of the composite primary outcome), patients with CRP levels of 1–3 mg/L showed a higher risk death (HR:1.43, 95% CI:1.24–1.64), HF (HR 1.08, 95% CI 1.01–1.16), AF (HR 1.10, 95% CI 1.02–1.18) and ventricular arrhythmias (HR 1.25, 95%CI 1.02–1.52), compared to those with CRP levels of < 1 mg/L. The gene discussed is CRP; the disease is atrial fibrillation.