Finally, the proliferation and migration ability of DU145 and PC3 cells were significantly decreased after PD0325901 treatment.<h4>Conclusions</h4>SALL4 predicts unfavorable outcome and is closely associated with PCa progression, suggesting that SALL4 may be a promising prognostic marker and potential therapeutic target for PCa. Here, SALL4 is linked to posterior cortical atrophy.