The changes in CYP function were incorporated into a virtual mild COVID‐19 population, and it was observed that it would take more than 5000 volunteers in both the healthy and COVID‐19 cohorts to detect a >25% increase in the HCQ AUC, although a statistically‐significant change in the HCQ AUC and Cmax could be observed with 10 trials of n = 500 participants (5000 total in each arm). Here, PPIG is linked to COVID-19.