GRN and Alzheimer disease: Patients with FTD-GRN exhibit greater cleavage of progranulin to granulins in a degenerated region of frontal cortex than in occipital cortex [63], but this higher cleavage of progranulin may be driven by neurodegeneration or inflammation, as it is also observed in degenerated regions of patients with sporadic FTLD-TDP type A and AD [73].