The increases in neuronal CatD (Additional file 1: Fig. S1, Fig. 4) and lysosomal storage material (Additional file 1: Fig. S4) are consistent with prior studies of FTD-GRN [40, 90] and FTD-CHMP2B [28], and may be a sign of neuronal lysosomal dysfunction. This evidence concerns the gene GRN and frontotemporal dementia.