GRN and frontotemporal dementia: The more dramatic increase in lysosomal proteins in frontal cortex than in occipital cortex of patients with FTD-GRN, as well as the presence of similar increases in patients with sporadic FTLD-TDP type A, suggested that these changes may be more associated with aspects of FTLD-TDP type A pathology such as TDP-opathy, neurodegeneration, or neuroinflammation than with progranulin insufficiency.