USP37 and osteosarcoma: In order to validate our finding further, we treated cells that overexpressed USP37 with HU and immuno-stained osteosarcoma cells with Anti USP37 antibody as well as Anti 53BP1 and Anti Replication protein A antibody to assess to resolution of these DNA damage foci in cells that were over expressing USP37 as compared to cells in which its expression was low.