COPS5 and ovarian neoplasm: There are five main families of DUBs, each with its own unique characteristics: ubiquitin-specific proteases (USPs), ovarian tumor proteases (OTUs), ubiquitin C-terminal hydrolases (UCHs), Machado-Joseph disease protein domain proteases (MJDs), and Jab1/Mov34/Mpr1 Pad1 N-terminal + MPN + (JAMM) motif proteases [12].