To further analyze the dysregulated gene set in osteosarcoma cells after USP37 overexpression and knockdown, we used a ± 2 Log2 fold cut-off and identified a total of 349 genes dysregulated in the OE condition and 302 genes dysregulated in the KO condition compared to wild type (Fig. 2Di) [25]. This evidence concerns the gene USP37 and osteosarcoma.