Various glycosaminoglycans (hyaluronic acid, heparin) and proteoglycans (CD44, CSPG4, MUC-1) have been suggested as potential cancer targets due to their important roles in tumor pathogenesis and their upregulation in malignant tissues [14, 16, 18, 50, 51] but are also expressed in healthy tissues. This evidence concerns the gene CD44 and cancer.