This study clarified that SATB2-AS1, as one of the good prognostic factors of HCC, affects HCC progression by regulating the miR-3678-3p/GRIM-19/STAT3/HIF-1α pathway expression, providing a novel intervention target for the clinical treatment and prognosis of HCC (Fig. 10). This evidence concerns the gene STAT3 and hepatocellular carcinoma.