In addition, the expression of RGS12 is significantly reduced in oral squamous cell carcinoma (OSCC) tissues, and overexpression of RGS12 represses OSCC cell proliferation and migration through regulating the phosphorylation and SUMOylation of phosphatase and tension homolog (PTEN) [112]. The gene discussed is RGS12; the disease is oral cavity squamous cell carcinoma.