For example, some RGS proteins including RGS4, RGS16, RGS2, RGS6 and RGS17 negatively regulate the progression of breast cancer, whereas RGS20 protein exerts the positive effects on potentiating the carcinogenesis of breast cancer [84, 105, 115, 126–128]. The gene discussed is RGS4; the disease is breast carcinoma.