Likewise, the alterations in methylation status of RGS2 gene promoter were later discovered in prostate cancer cells, where the protein expression of RGS2 was inversely correlated with the methylation status of RGS2 gene promoter, while suppression of RGS2 DNA methylation effectively attenuated the protein expression of RGS2 in those cells, proving RGS2 expression is precisely controlled by the mediation in its gene promoter [72]. This evidence concerns the gene RGS2 and Familial prostate cancer.